616.234.5000

Publications

Van Raamsdonk Laboratory

Selected Publications

Ghosh A, Tyson T, George S, Hildebrandt EN, Steiner JA, Madaj Z, Schulz E, Machiela E, McDonald WG, Escobar Galvis ML, Kordower JH, Van Raamsdonk JM, Colca JR, Brundin P. 2016. Mitochondrial pyruvate carrier regulates autophagy, inflammation and neurodegeneration in experimental models of Parkinson’s disease. Sci Transl Med 8(368):368ra174     Article

Dues DJ, Andrews EK, Schaar CE, Bergsma AL, Senchuk MM, Van Raamsdonk JM. 2016. Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways. Aging 8(4):777–795.      PubMed        Article

Schaar CE, Dues DJ, Spielbauer KK, Machiela E, Cooper JF, Senchuk M, Hekimi S, Van Raamsdonk JM. 2015. Mitochondrial and cytoplasmic ROS have opposing effects on lifespan. PLoS Genetics 11(2): e1004972.      PubMed       Article

Cooper JF, Dues DJ, Spielbauer KK, Machiela E, Senchuk MM, Van Raamsdonk JM. 2015. Delaying aging is neuroprotective in Parkinson’s disease: a genetic analysis in C. elegans models. NPJ Parkinsons Dis 1:15022.      Article

Machiela E, Dues DJ, Senchuk MM, Van Raamsdonk JM. 2016. Oxidative stress is increased in C. elegans models of Huntington’s disease but does not contribute to polyglutamine toxicity phenotypes. Neurobiol Dis 96:1–11.     Article

Van Raamsdonk JM, Hekimi S. 2012. Superoxide dismutase is dispensable for normal animal lifespan. Proc Natl Acad Sci USA 109(15):5785-90.                PubMed           Article

Van Raamsdonk JM, Hekimi S. 2011. FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1. Mech Ageing Dev 132(10):519-521.    PubMed           Article

Van Raamsdonk JM, Hekimi S. 2010. Reactive oxygen species and aging in Caenorhabditis elegans: Causal or casual relationship? Antiox Redox Signal 13(12):1911-53.     PubMed

Van Raamsdonk JM, Meng Y, Camp D, Yang W, Jia X, Bénard C, Hekimi S. 2010. Decreased energy metabolism extends lifespan in Caenorhabditis elegans without reducing oxidative damage. Genetics 185(2):559-71.     PubMed     Article

Van Raamsdonk JM, Hekimi S. 2009. Deletion of the mitochondrial superoxide dismutase sod-2 extends lfespan in Caenorhabditis elegans. PLOS Genetics 5(2), e1000361.      PubMed           Article

Van Raamsdonk JM, Gibson WT, Pearson J, Murphy Z, Lu G, Leavitt BR, Hayden MR. 2006. Body weight is modulated by levels of full-length Huntingtin. Hum Mol Genet 15(9):1513-1523.      PubMed           Article

Van Raamsdonk JM, Murphy Z, Pearson J, Slow EJ, Leavitt BR, Hayden MR. 2005. Selective degeneration and nuclear localization of mutant Huntingtin in the YAC128 mouse model of Huntington disease. Hum Mol Genet 14(24):3823-35.      PubMed           Article

Van Raamsdonk JM, Pearson J, Rogers D, Bissada N, Vogl AW, Hayden MR, Leavitt BR. 2005. Loss of wild type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease. Hum Mol Genet 10(14):1379-1392.      PubMed           Article

Van Raamsdonk JM, Pearson J, Slow EJ, Hossain SM, Leavitt BR, Hayden MR. 2005. Dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington’s disease. J. Neurosci 25(16):4169-80.      PubMed          Article

Slow, EJ, Van Raamsdonk JM, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Yang Y-Z, Bissada N, Li X-J, Simpson EM, Gutekunst C-A, Leavitt BR, Hayden MR. 2003. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum Mol Genet 12(13):1555-1567.      PubMed           Article